Immunogenicity
Development of a validated novel bead extraction method for the detection of anti-PEG antibodies in human serum
Polyethylene glycol (PEG) is used in many applications including drug development. Due to exposure to environmental products, there is a high prevalence of preexisting anti-PEG…
Webinar Recording: Immunogenicity assessment of gene therapy compounds: discussion on current and future concepts
After a series of setbacks in the nineties, several gene therapies have now been approved by health agencies worldwide. As a consequence, the number of these…
Webinar Recording: Clinical relevance of (unwanted drug-induced) immune responses
Ultimately, all biological drugs are immunogenic. Over the last several years, methods for the detection of drug-induced antibodies have become more sensitive, which means that…
Webinar on Demand: Recent Aspects and Challenges in the Assessment of Immunogenicity
The assessment of immunogenicity of biological protein drugs is a key component in drug development. A basic knowledge in immunology is a prerequisite for understanding…
Managing unwanted immunogenicity of therapeutic proteins
Deehan M, Garcês S, Kramer D, Baker M, Rat D, Roettger Y, Kromminga A. Managing unwanted immunogenicity of therapeutic proteins. Autoimmunity Rev. 2015;14,569-574. Abstract All…
2016 White Paper, Recent Issues in Bioanalysis Part 3 – LBA, Biomarkers, and Immunogenicity
2016 White Paper on recent issues in bioanalysis focus on biomarker assay validation BAV Part 3 – LBA, biomarkers and immunogenicity