Posters
Pharmacokinetics of AC220 and its Active Metabolite AC886, a FLT-3 Inhibitor, Following Sequential Oral Dose Escalation to Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)
AC220, a FLT-3 inhibitor, is being investigated for the treatment of Acute Myeloid Leukemia (AML). The objective of this study was to investigate the safety,…
Effect of Food on the Pharmacokinetics of Ulifloxacin, a Fluoroquinolone for Bacterial Gastroenteritis Treatment, in Healthy Subjects After Oral Dosing of the Prodrug Prulifloxacin
To investigate the effect of food on the pharmacokinetics (PK) of ulifloxacin in healthy individuals following a single oral dosing of the prodrug prulifloxacin at…
Comparison of Encapsulated and Non-encapsulated Doxorubicin Pharmacokinetics Following Single Intravenous Administration of ATI-0918, an Encapsulated Liposomal Formulation, and DOXIL® in Female Rats
To compare the pharmacokinetics (PK) of encapsulated and non encapsulated doxorubicin following a 6 mg/kg IV bolus dose of ATI-0918 or DOXIL® (CAELYX®) in female…
Pharmacokinetics of Subcutaneously-administered CBX129801, A Long-acting Synthetic C-Peptide in Patients with Type 1 Diabetes Mellitus
To assess the pharmacokinetics (PK) of CBX129801, a long-acting synthetic C-peptide, following subcutaneous (SC) injection in patients with type 1 diabetes mellitus (T1DM).
Pharmacokinetic Bioequivalence of ATI-0918 and DOXIL®/CAELYX® in Patients with Ovarian Cancer
To assess the pharmacokinetic (PK) bioequivalence of ATI-0918 (test product) and DOXIL®/CAELYX® (reference product).
Use of Cold Compounds and High Resolution Mass Spectrometry to Quickly Characterize Drug Uptake in Cryopreserved Human Hepatocytes
Using cold compounds, we wanted to present a compelling set of data to show that hepatocytes and HRAM spectrometry can be used to obtain at…
Validated Multi-site GLP-compliant Analysis of Solithromycin (SOLI) in Monkey Plasma Samples Following Filtration to Remove Potentially Active Anthrax Spores
A highly sensitive method was developed and validated to allow monkey plasma samples, potentially containing Bacillus anthracis (B. anthracis) spores
A Quantitative Method for Determining Hyaluronan Content in Plasma by LC/MS/MS and Plasma HA as a PharmacodynamicMarker for PEGylated-Hyaluronidase PH20 (PEGPH20) in a Phase 1b Trial for Pancreatic Ductal Adenocarcinoma
Hyaluronan (HA) is a non-sulfated linear glycosaminoglycan comprised of repeating disaccharide units of n acetylglucosamineand glucuronic acid.
Evaluation of the MSD Multiplex Electrochemiluminescent Immunoassy for the Determination of Cardiac Toxicity Biomarkers in Rat Serum
Published by BioAgilytixIntroductionICH guidelines require that preclinical safety pharmacology studies to assess the risk of cardiotoxicity be conducted before beginning any clinical development program. Investigation…
Evaluation of Multiplex Electrochemiluminescent Immunoassays for Quantitative Determination of Kidney Injury Biomarkers in Rat Urine
Published by BioAgilytixIntroduction Traditional clinical markers of kidney injury, such as BUN and serum creatinine, lack sufficient sensitivity for early detection of injury and are…